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A pulse sequence for singlet to heteronuclear magnetization transfer: S2hM.

Gabriele Stevanato1, James Eills2, Christian Bengs2

  • 1Chemistry, University of Southampton, Southampton, United Kingdom; Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|March 18, 2017
PubMed
Summary

We developed a new method, Singlet to heteronuclear Magnetisation (S2hM), to efficiently convert hyperpolarized proton singlet order into heteronuclear magnetization. This technique is robust and suitable for widespread use in para-hydrogen induced polarization applications.

Keywords:
HyperpolarizationM2SPolarization transferS2hMSinglet state

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Area of Science:

  • Magnetic Resonance Imaging
  • Hyperpolarization Techniques
  • Quantum Information

Background:

  • Para-hydrogen induced polarization (PHIP) enhances NMR/MRI signal.
  • Efficient conversion of hyperpolarized states is crucial for advanced applications.
  • Existing methods face limitations in robustness and efficiency.

Purpose of the Study:

  • Introduce and detail the Singlet to heteronuclear Magnetisation (S2hM) sequence.
  • Demonstrate the theoretical and experimental feasibility of S2hM.
  • Evaluate the robustness and efficiency of S2hM for hyperpolarization.

Main Methods:

  • Theoretical description of the S2hM sequence.
  • Experimental validation using thermally polarized samples.
  • Assessment of robustness against frequency and radiofrequency field variations.

Main Results:

  • S2hM efficiently converts singlet order to heteronuclear magnetization.
  • The method shows robustness to frequency offset mismatches.
  • High conversion efficiency observed across different magnetic equivalence regimes.

Conclusions:

  • S2hM is a robust and efficient method for hyperpolarized magnetization transfer.
  • The sequence is simple to implement and optimize.
  • S2hM is a promising tool for widespread adoption in PHIP applications.