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Relationship Between Ktrans and K1 with Simultaneous Versus Separate MR/PET in Rabbits with VX2 Tumors
Kyung Hee Lee1,2, Seung Kwan Kang3,4, Jin Mo Goo5,6,7
1Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background/Aim:
To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic 13N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model.
Materials And Methods:
MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K1 values were estimated using an in-house software program. The relationships between Ktrans and K1 were analyzed using Pearson's correlation coefficients and linear/non-linear regression function.
Results:
Assuming a linear relationship, Ktrans and K1 exhibited a moderate positive correlations with both simultaneous (r=0.54-0.57) and separate (r=0.53-0.69) imaging. However, while the Ktrans and K1 from separate imaging were linearly correlated, those from simultaneous imaging exhibited a non-linear relationship. The amount of change in K1 associated with a unit increase in Ktrans varied depending on Ktrans values.
Conclusion:
The relationship between Ktrans and K1 may be mis-interpreted with separate MR and PET acquisition.
