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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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A Single Institutional Analysis of Systemic Therapy for Unresectable or Recurrent Small Bowel Adenocarcinoma

Shunichiro Makino1, Hidekazu Takahashi2, Naotsugu Haraguchi1

  • 1Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.

Anticancer Research
|March 19, 2017
PubMed
Abstract

Insights

Systemic therapy with fluorouracil or fluoropyrimidine regimens offers a promising option for unresectable or recurrent small bowel adenocarcinoma (SBA). Patients receiving a single treatment line showed significantly longer survival than those receiving multiple lines.

Area of Science:

  • Oncology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Small bowel adenocarcinoma (SBA) is a rare gastrointestinal malignancy.
  • Systemic treatment is the primary therapeutic option for unresectable or recurrent SBA.

Purpose of the Study:

  • To evaluate the efficacy of fluorouracil- or fluoropyrimidine-based regimens in patients with SBA.
  • To analyze factors associated with progression-free interval (PFI) in SBA patients.

Main Methods:

  • Retrospective study of 13 patients with SBA.
  • Analysis of treatment regimens and patient characteristics.
  • Assessment of overall survival (OS) and relapse-free survival (RFS).

Main Results:

  • The 5-year OS for SBA patients was 23.5%.
  • The 5-year RFS for curatively resected SBA was 45%.
  • Patients with unresectable/recurrent SBA (n=10) had a median OS of 28.0 months. Survival was longer for patients receiving one treatment line versus multiple lines.

Conclusions:

  • Fluorouracil- or fluoropyrimidine-based regimens may effectively treat unresectable or recurrent SBA.
  • Single-line treatment regimens were associated with improved survival in SBA patients.
Keywords:
Unresectablechemotherapyrecurrentsmall bowel adenocarcinoma

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