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Enabling Chemistry Technologies and Parallel Synthesis-Accelerators of Drug Discovery Programmes
A Vasudevan1, A R Bogdan1, H F Koolman1
1Discovery Chemistry and Technology, North Chicago, IL, United States.
Progress in Medicinal Chemistry
|March 19, 2017
Summary
Pharmaceutical companies can boost productivity by investing in new chemistry technologies. These innovations reduce cycle times, lower costs, and improve the success rate for synthesizing novel drug candidates and in parallel synthesis.
Area of Science:
- Medicinal Chemistry
- Process Chemistry
- Pharmaceutical Development
Background:
- The pharmaceutical industry faces challenges in optimizing productivity.
- Investments in advanced chemistry technologies are crucial for improving efficiency.
- Key metrics impacted include cycle times, cost of goods, and technical success rates.
Purpose of the Study:
- To highlight chemistry technologies that enhance pharmaceutical productivity.
- To showcase applications in novel scaffold synthesis and parallel synthesis.
- To provide insights from AbbVie's development and implementation experiences.
Main Methods:
- Review and description of implemented chemistry technologies.
- Case studies on applications in novel scaffold synthesis.
- Examples of parallel synthesis strategies utilizing these technologies.
Main Results:
- Demonstrated impact of specific technologies on reducing cycle times.
- Evidence of cost reductions in the cost of goods.
- Improved probability of technical success in drug development projects.
- Successful application in generating diverse chemical libraries.
Conclusions:
- Strategic investment in chemistry technologies is vital for pharmaceutical productivity.
- These technologies enable efficient synthesis of novel molecular architectures.
- AbbVie's experience underscores the value of technological innovation in drug discovery and development.
