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Acceleration of recovery from sciatic nerve damage by the ACTH (4-9) analog Org 2766: different routes of
A J Dekker1, M M Princen, H De Nijs
1Scientific Development Group, Organon International BV, Oss, The Netherlands.
Peptides
|November 1, 1987
Abstract:
Functional recovery following a sciatic nerve crush in rats was investigated by measuring the reflex withdrawal of the hindpaw to a hot air stream. The ACTH(4-9) analog Org 2766 accelerated recovery when administered subcutaneously (two-daily injections: 10 micrograms/animal; minipumps: 20-40 micrograms/animal per 24 hr: biodegradable microspheres: 40 micrograms/animal per 24 hr), but oral administration (1.5-20 mg/animal daily, in the drinking water; 1.5-15 mg/animal daily, by gavage) was not effective.