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Increased Fibrinogen to Albumin Ratio in Ischemic Retinal Vein Occlusions

Hande Guclu1, Sadık A Ozal1, Vuslat Pelitli Gurlu1

  • 11 Department of Ophthalmology, Trakya University, Faculty of Medicine, Edirne - Turkey.

European Journal of Ophthalmology
|March 19, 2017
PubMed

Insights

The fibrinogen to albumin ratio can help identify retinal vein occlusion (RVO) with ischemia. This blood test offers a simpler alternative to retinal angiograms for predicting ischemic RVO.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Biochemistry

Background:

  • Retinal vein occlusion (RVO) is a common cause of vision loss.
  • Ischemia is a key factor in RVO severity and prognosis.
  • Current diagnostic methods for ischemia can be invasive.

Purpose of the Study:

  • To investigate the association between plasma fibrinogen and serum albumin levels and ischemia in RVO patients.
  • To evaluate the fibrinogen to albumin ratio as a potential biomarker for ischemic RVO.

Main Methods:

  • A total of 166 subjects were included: 44 with central RVO (CRVO), 68 with branch RVO (BRVO), and 54 controls.
  • Comprehensive ophthalmologic and physical examinations were performed.
  • Biochemical parameters, including fibrinogen and albumin levels, were analyzed.

Main Results:

  • Patients with ischemic CRVO and BRVO exhibited higher fibrinogen to albumin ratios and fibrinogen levels compared to controls.
  • A significant positive correlation was observed between ischemia and both the fibrinogen to albumin ratio (r=0.732, p=0.001) and fibrinogen level (r=0.669, p=0.001).

Conclusions:

  • The fibrinogen to albumin ratio is significantly associated with ischemic RVO.
  • This ratio serves as a valuable, non-invasive initial diagnostic marker for predicting ischemia in RVO.
  • It offers a simpler alternative to retinal angiograms for assessing RVO ischemia.
Abstract

Keywords:
Branch retinal vein occlusionCentral retinal vein occlusionFibrinogen to albumin ratioIschemiaThrombophilia

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