Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

698
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
698
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

752
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
752
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

866
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
866
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.8K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.8K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

988
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
988

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and Evaluation of the Personal Patient Profile-Bladder Cancer (P3-BC): A Web-Based Decision Support System for Patients Considering Cystectomy and Urinary Diversion.

Cancers·2026
Same author

User-Centered Development of the MyCare<sup>2</sup> Comprehensive Digital Support Platform for Caregivers of Individuals With Cancer.

JCO clinical cancer informatics·2026
Same author

Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial.

JAMA·2026
Same author

A web-based application to promote palliative care in advanced ovarian cancer: A pre-post design.

Gynecologic oncology reports·2026
Same author

Digital health interventions for urinary tract infection prevention and management in people living with dementia and their family caregivers: a scoping review.

The Gerontologist·2025
Same author

Cultural Adaptation of Helping Her Heal, an Educational Counseling Intervention for Spouse Caregivers of Women With Breast Cancer in Ghana.

Oncology nursing forum·2025

Related Experiment Video

Updated: Mar 6, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

24.1K

Self-Administered Premedication: Improving Taxane Chemotherapy Treatment
.

Kristin Roper1, Mary Lou Siefert1, Frances Fuller2

  • 1Dana-Farber Cancer Institute.

Clinical Journal of Oncology Nursing
|March 19, 2017
PubMed
Summary

Implementing a new protocol for taxane therapy premedication significantly improved patient adherence and reduced hypersensitivity reaction risks. Standardized documentation and patient teaching in the electronic health record (EHR) were key to achieving 90% adherence.

Keywords:
electronic health recordshypersensitivity reactionspremedicationtaxanes

More Related Videos

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

11.1K
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

7.8K

Related Experiment Videos

Last Updated: Mar 6, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

24.1K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

11.1K
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

7.8K

Area of Science:

  • Oncology Nursing
  • Patient Safety
  • Healthcare Informatics

Background:

  • Taxane chemotherapy necessitates premedication to prevent hypersensitivity reactions.
  • Effective patient education and adherence to premedication regimens are crucial for managing these risks.
  • Current practices may lack standardization in documenting and reinforcing premedication protocols.

Purpose of the Study:

  • To implement and evaluate a multidisciplinary protocol for managing taxane therapy premedication.
  • To integrate standardized nursing documentation, patient teaching, and adherence monitoring into the electronic health record (EHR).
  • To assess the impact of the protocol on patient adherence to at-home premedication.

Main Methods:

  • Development of standardized prescriptions and patient instruction materials.
  • Implementation of a standardized approach for documenting premedication adherence and teaching within the EHR.
  • Utilizing pre- and post-implementation EHR audits to evaluate practice changes and adherence rates.

Main Results:

  • Initial audit indicated improvements across all practice change metrics.
  • Reinforcement strategies, including group and individual meetings, were employed after the first audit.
  • The study successfully achieved the target of 90% patient adherence to premedication by the second audit.

Conclusions:

  • A multidisciplinary protocol integrated into the EHR can effectively improve premedication adherence in patients receiving taxane therapy.
  • Standardized documentation and patient education are vital components for enhancing patient safety and preventing hypersensitivity reactions.
  • The EHR serves as a valuable tool for monitoring and ensuring adherence to critical treatment protocols.