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Related Concept Videos

Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

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The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
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Parallel Processing01:20

Parallel Processing

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The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
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Somatosensation01:33

Somatosensation

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Major Somatic Sensory Pathways01:28

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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What is a Sensory System?01:31

What is a Sensory System?

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Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.
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Visual Agnosia01:12

Visual Agnosia

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Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
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Related Experiment Video

Updated: Mar 6, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
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Sensory processing in Huntington's disease.

Ana Mirallave1, Merche Morales2, Christopher Cabib2

  • 1EMG Unit, Neurology Department, Hospital Clinic, Facultat de Medicina, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain; Center for Neural Science (CNS), New York University (NYU), USA.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|March 19, 2017
PubMed
Summary
This summary is machine-generated.

Huntington's disease patients show delayed sensory processing, not impaired conscious perception. Their faulty sensorimotor integration worsens with reaction tasks, indicating a failure to detect stimulus salience.

Keywords:
Conscious perceptionEvoked potentialsHuntington’s diseaseReaction timeSensory processing

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Area of Science:

  • Neuroscience
  • Electrophysiology
  • Human Physiology

Background:

  • Huntington's disease (HD) is characterized by electrophysiological abnormalities, including delayed somatosensory long-latency evoked potentials (LLeps).
  • The relationship between these electrophysiological deficits and conscious perception in HD remains unclear.

Purpose of the Study:

  • To investigate if electrophysiological dysfunction in Huntington's disease is linked to delayed conscious perception of sensory stimuli.
  • To explore the impact of reaction tasks on sensory processing in HD patients.

Main Methods:

  • 16 Huntington's disease patients and 16 controls performed a sensory perception task using Libet's clock.
  • Electrical or thermal stimuli were used, with tasks involving stimulus perception (AW) and a simple reaction time task (SRT).
  • Long-latency evoked potentials (LLeps) were recorded.

Main Results:

  • LLeps and SRT were significantly delayed in HD patients across all conditions.
  • Abnormal prolongation of AW was observed only in the reaction task condition.
  • A negative correlation between SRT and AW/LLeps amplitude was found in HD patients.

Conclusions:

  • HD patients exhibit preserved subjective perception of sensory stimuli.
  • Electrophysiological abnormalities in LLeps are more pronounced during reaction tasks in HD patients.
  • Findings suggest faulty sensorimotor integration rather than a primary cognitive deficit in early-stage HD.