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The critical gap for pediatric reference intervals of complete blood count in China

Yaqi Lv1, Guoshuang Feng2, Xin Ni2

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing 100069, China; Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, No.56 Nanlishi Road, Beijing 100045, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 20, 2017
PubMed

Insights

Existing pediatric reference intervals (RIs) in China show significant gaps. New research is crucial to establish accurate complete blood count (CBC) RIs for Chinese children, ensuring reliable health assessments.

Area of Science:

  • Clinical Chemistry
  • Pediatric Hematology

Background:

  • A critical gap exists in pediatric reference intervals (RIs) for complete blood count (CBC) in China.
  • Existing RIs require validation to ensure their applicability to the Chinese pediatric population.

Purpose of the Study:

  • To validate three existing pediatric RIs for CBC in a Chinese cohort.
  • To assess the applicability of current RIs for pediatric health examinations in China.

Main Methods:

  • A total of 2255 healthy children in Beijing Children's Hospital provided blood samples.
  • Complete blood count (CBC) parameters including RBC, HGB, HCT, PLT, and WBC were measured using a Sysmex Xs-800i analyzer.
  • Out-of-range (OOR) values were calculated against three different RIs to evaluate their accuracy.

Main Results:

  • Significant deviations (10%–91.9%) were observed when comparing existing RIs with the study data, particularly for RBC, HGB, WBC, and PLT.
  • Lower side OOR for WBC count reached 64%, and upper side OORs for WBC and PLT exceeded 10% compared to adult RIs.
  • Lower side OORs for RBC, HGB, and HCT were over 10% in boys under 14, suggesting RIs validated by Beijing Children's Hospital showed relative accuracy.

Conclusions:

  • A clear need for pediatric RIs in China has been identified.
  • Initiating research to establish and validate specific pediatric RIs for CBC in China is imperative.
Abstract

Keywords:
Complete blood countOut of rangePediatricsReference interval

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