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Updated: Mar 6, 2026

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
Drug-Induced Liver Injury in HIV Patients
Guy W Neff1, Dushyantha Jayaweera1, Kenneth E Sherman1
1Dr. Neff serves as Medical Director of Liver Transplantation and Dr. Sherman is Program Director in the Department of Medicine at the University of Cincinnati. Dr. Jayaweera is in the Department of Medicine at the University of Miami.
Abstract:
The treatment of HIV has improved over the last decade due in part to the success of treatment with combination-therapy drug "cocktails," better referred to as highly active antiretroviral therapy. The safety and efficacy of these regimens is often complicated by the presence of infectious hepatitis and occurrence of drug-induced liver injury. In most patients, these complications manifest as mild laboratory abnormalities and exist without clinical consequence. However, acute and chronic hepatic injury may lead to increased morbidity and mortality. It is essential to identify all potential causes of liver injury to correctly implement steps to alleviate the condition while maintaining optimal control of HIV viremia.
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The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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