Population attributable danger of hereditary heart breaks. Risk factors among newborns in Yazd, Iran

M Taheri1, A Dehghani1, M Noorishadkam2

  • 1Faculty of Health, Department of Biostatistics & Epidemiology, Shahid Sadoughi University of Medical Sciences ,Yazd, Iran.

Insights

Maternal obesity and overweight are significant risk factors for congenital heart defects in newborns. These factors, alongside a history of stillbirth and lack of prenatal multivitamins, contribute substantially to heart malformations.

Area of Science:

  • Cardiology
  • Pediatrics
  • Public Health

Background:

  • Congenital heart defects (CHDs) are heart conditions present at birth, varying in severity.
  • These conditions can impact a newborn's heart function from mild to severe.

Purpose of the Study:

  • To evaluate risk parameters for congenital heart defects using Population Attributable Risk (PAR).
  • To identify and prioritize risk factors contributing to CHDs in newborns.

Main Methods:

  • A case-control study conducted in Yazd hospitals from 2012-2013.
  • Echocardiography used for defect identification, classified via ICD-10.
  • PAR and Levin's formula applied to assess risk factor impact.

Main Results:

  • Maternal history of stillbirth, lack of prenatal multivitamin use, and maternal obesity/overweight identified as key risk factors.
  • Overweight and obesity showed the highest attributable fraction for congenital heart malformations.
  • Despite weaker individual association, overweight and obesity have higher prevalence and greater attributable risk.

Conclusions:

  • Multiple factors contribute to congenital heart defects.
  • Overweight and obesity are significant contributors to CHDs due to their high prevalence and attributable risk.

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