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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Speculative Considerations about Some Cardiology Enigmas
Paulo Roberto Barbosa Evora1, Andre Schmidt2, Livia Arcêncio2
1Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes, 3900 - Monte Alegre - CEP: 14049-900 Ribeirão Preto/SP. Brazil.
Background:
Enigmas often lead to hypotheses and speculations. For this reason, especially for the sake of the reader's motivation, we opted for the plain discussion of some cardiology enigmas.
Objective:
The present text was aimed to discuss speculatively some cardiology enigmas.
Method:
Text was freely designed in the context of coronary artery and heart valve diseases.
Results:
The results were presented as the combination enigma/hypothesis. 1) The absence of arteriosclerosis in intramyocardial coronary arteries/ endothelium-myocardial interaction (crosstalk); 2) The unique and always confirmed superior evolution of the internal thoracic artery as coronary graft/ higher NO basal release 3) The prophylactic left internal thoracic artery graft in mildlystenosed coronary lesions/need of more accurate functional imaging techniques; 4) The high incidence of perioperative atrial fibrillation in patients with coronary artery disease/atrial ischemia associated to left circumflex coronary lesions; 5) The handling of disease-free saphenous vein grafts at the time of reoperation/biological serendipity with graft vein segments; 6) The possible aortic stenosis protection against coronary artery disease/ endothelium-myocardium interaction (crosstalk) improving NO release.
Conclusion:
The discussed topics associated with their respective speculative hypothesis remain as enigmas, but would become motivations for investigations.
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