Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.0K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Skin Cancer01:30

Skin Cancer

6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K
Pigmentation01:19

Pigmentation

4.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.8K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

503
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
503
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.4K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid efficacy of anifrolumab in refractory cutaneous dermatomyositis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype.

The Journal of experimental medicine·2026
Same author

Telocyte-derived pentraxin 3 enables vascular pruning as a key driver in infantile hemangioma regression.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Impact of atopic dermatitis on education and career choices: the Scars of Life international study.

The Journal of investigative dermatology·2026
Same author

The Long-Term Impact of Childhood and Adolescent Atopic Dermatitis on Physical and Psychosocial Well-Being: Scars of Life project.

Clinical and experimental dermatology·2026
Same author

More than a symptom: itch as an independent clinical contributor in atopic dermatitis - a global-scale study on 15,223 patients.

The British journal of dermatology·2026

Related Experiment Video

Updated: Mar 6, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.1K

Special Considerations in Children with Vitiligo.

Alain Taïeb1, Julien Seneschal1, Juliette Mazereeuw-Hautier2

  • 1Service de Dermatologie Adulte et Pédiatrique, Centre de Référence des Maladies Rares de la Peau, Hôpital Saint André, 1 rue Jean Burguet, Bordeaux 33075, France; INSERM 1035, University of Bordeaux, Bordeaux 33000, France.

Dermatologic Clinics
|March 21, 2017
PubMed
Summary

Childhood vitiligo presents unique characteristics compared to adult cases, including a higher likelihood of segmental vitiligo and associated autoimmune conditions. Early diagnosis is key for successful treatment outcomes in children.

Keywords:
ChildDifferential diagnosisHypopigmentationTherapyVitiligo

More Related Videos

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.7K
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Related Experiment Videos

Last Updated: Mar 6, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.1K
Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.7K
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Area of Science:

  • Dermatology
  • Pediatric Autoimmune Diseases

Background:

  • Childhood vitiligo exhibits distinct clinical features differentiating it from adult-onset vitiligo.
  • Key differences include a higher incidence of the segmental variant, increased prevalence of halo nevi, and a more frequent family history of autoimmune diseases and atopic diathesis.

Purpose of the Study:

  • To delineate the unique epidemiological and clinical characteristics of childhood vitiligo.
  • To identify key differential diagnoses for childhood vitiligo variants.
  • To explore the implications of early diagnosis on therapeutic outcomes in pediatric patients.

Main Methods:

  • Comparative analysis of clinical features between childhood and adult-onset vitiligo.
  • Review of differential diagnoses for segmental and nonsegmental vitiligo in children.
  • Correlation analysis between diagnostic timing and treatment efficacy in pediatric vitiligo cases.

Main Results:

  • Childhood vitiligo shows a greater prevalence of the segmental form, halo nevi, and familial autoimmune/atopic history.
  • Primary differential diagnoses include postinflammatory hypomelanoses (for nonsegmental) and nevus depigmentosus (for segmental) vitiligo.
  • Early diagnostic recognition in children is associated with favorable treatment responses.

Conclusions:

  • Childhood vitiligo is clinically distinct from adult vitiligo, necessitating specific diagnostic considerations.
  • Accurate differentiation from conditions like nevus depigmentosus is crucial for appropriate management.
  • Timely diagnosis and intervention in pediatric vitiligo significantly improve therapeutic outcomes.