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Engineering a lipase B from Candida antactica with efficient perhydrolysis performance by eliminating its hydrolase
Xu-Ping Wang1, Peng-Fei Zhou2, Zhi-Gang Li2
1School of Food Sciences and Engineering, South China University of Technology, Wushan road 381, Tianhe District, 510640 Guangzhou, P.R. China.
Scientific Reports
|March 21, 2017
Abstract:
A Ser105Ala mutant of the lipase B from Candida antarctica enables 'perhydrolase-only' reactions. At the example of the chemoenzymatic Baeyer-Villiger oxidation of cyclohexanone, we demonstrate that with this mutant selective oxidation can be achieved in deep eutectic solvent while essentially eliminating the undesired hydrolysis reaction of the product.
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