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Updated: Mar 6, 2026

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Zika virus induced cellular remodelling.

Evan D Rossignol1, Kristen N Peters2, John H Connor2

  • 1Department of Physiology & Biophysics, Boston University School of Medicine, Boston, MA, USA.

Cellular Microbiology
|March 21, 2017
PubMed
Summary
This summary is machine-generated.

Zika virus (ZIKV) infection remodels intracellular membranes, revealing its replication cycle within mammalian cells. This study details viral RNA replication, assembly, maturation, and egress, aligning with flavivirus replication models.

Keywords:
disease processesinfectionmembranemicrobial-cell interactionvirulenceviruses (phages)

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Area of Science:

  • Virology
  • Cell Biology
  • Microbiology

Background:

  • Zika virus (ZIKV) causes severe morbidities like microcephaly and Guillain-Barré syndrome.
  • Understanding ZIKV replication is crucial due to its public health threat and knowledge gaps.

Purpose of the Study:

  • To elucidate the ZIKV replication cycle in mammalian cells.
  • To detail the 3D ultrastructural organization of ZIKV replication stages.

Main Methods:

  • Serial section 3-dimensional electron tomography was employed.
  • Infected mammalian cells were analyzed to visualize intracellular events.

Main Results:

  • ZIKV infection causes extensive remodeling of intracellular membranes, particularly the endoplasmic reticulum.
  • Structures for RNA replication and virus assembly were observed within the ER.
  • Viruses were visualized in the Golgi apparatus, indicating maturation and egress.

Conclusions:

  • The study provides detailed 3D ultrastructural insights into the ZIKV replication cycle.
  • ZIKV replication closely follows the established flavivirus replication paradigm.