Self-reported sleep disturbances associated with procedural learning impairment in adolescents at ultra-high risk for psychosis
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Jessica R Lunsford-Avery1, Derek J Dean2, Vijay A Mittal3
1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
Abstract:
Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased self-reported problems with sleep latency, efficiency, and quality were associated with impaired procedural learning rate. Further, within-sample comparisons revealed that UHR youth reporting better sleep displayed a steeper learning curve than those with poorer sleep. Sleep disturbances appear to contribute to cognitive/motor deficits in the UHR period and may play a role in psychosis etiology.
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