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Management of Periprosthetic Joint Infection: The More We Learn, the Less We Know
Robert A Henderson1, Matthew S Austin1
1Division of Adult Reconstruction, Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
The Journal of Arthroplasty
|March 21, 2017
Summary
Periprosthetic joint infection (PJI) is a rare complication after hip and knee replacements. Researching PJI is challenging due to its rarity and varied presentation, necessitating new study designs.
Area of Science:
- Orthopedic surgery
- Infectious diseases
- Biomedical research
Background:
- Total hip and knee arthroplasty are successful treatments for end-stage arthritis.
- Periprosthetic joint infection (PJI) is a rare but serious complication following these procedures.
Purpose of the Study:
- To review the challenges in studying periprosthetic joint infection (PJI).
- To propose a framework for future research into PJI.
Main Methods:
- Literature review focusing on the difficulties in PJI research.
- Analysis of study design limitations related to PJI's low incidence and heterogeneous nature.
Main Results:
- Studying PJI is difficult due to its low frequency, which impacts study power.
- Heterogeneity in clinical presentation complicates PJI diagnosis and treatment research.
Conclusions:
- Addressing PJI requires overcoming significant research challenges.
- A structured approach and new research algorithms are needed to advance understanding and treatment of PJI.
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