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Management of Periprosthetic Joint Infection: The More We Learn, the Less We Know

Robert A Henderson1, Matthew S Austin1

  • 1Division of Adult Reconstruction, Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.

The Journal of Arthroplasty
|March 21, 2017
PubMed
Abstract

Insights

Periprosthetic joint infection (PJI) is a rare complication after hip and knee replacements. Researching PJI is challenging due to its rarity and varied presentation, necessitating new study designs.

Area of Science:

  • Orthopedic surgery
  • Infectious diseases
  • Biomedical research

Background:

  • Total hip and knee arthroplasty are successful treatments for end-stage arthritis.
  • Periprosthetic joint infection (PJI) is a rare but serious complication following these procedures.

Purpose of the Study:

  • To review the challenges in studying periprosthetic joint infection (PJI).
  • To propose a framework for future research into PJI.

Main Methods:

  • Literature review focusing on the difficulties in PJI research.
  • Analysis of study design limitations related to PJI's low incidence and heterogeneous nature.

Main Results:

  • Studying PJI is difficult due to its low frequency, which impacts study power.
  • Heterogeneity in clinical presentation complicates PJI diagnosis and treatment research.

Conclusions:

  • Addressing PJI requires overcoming significant research challenges.
  • A structured approach and new research algorithms are needed to advance understanding and treatment of PJI.
Keywords:
diagnosis of PJImanagement of PJIperiprosthetic joint infectiontotal hip arthroplastytotal knee arthroplasty

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