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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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More Flavor for Flavonoid-Based Interventions?

Nadeem O Kaakoush1, Margaret J Morris1

  • 1School of Medical Sciences, University of New South Wales (UNSW) Sydney, Kensington, NSW 2052, Australia.

Trends in Molecular Medicine
|March 21, 2017
PubMed
Summary
This summary is machine-generated.

Poor diets contribute to obesity and cognitive decline. However, plant-derived flavonoids, especially after gut microbial conversion, may improve metabolic health and reverse cognitive impairment via the gut-brain axis.

Keywords:
cognitionflavonoidsgut microbiomeobesityobesogenic diet

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Area of Science:

  • Nutrition Science
  • Microbiology
  • Neuroscience

Background:

  • Poor dietary habits are linked to increased rates of obesity and diminished cognitive function.
  • Flavonoids, a class of plant compounds, show potential in improving metabolic health and mitigating cognitive decline.
  • The bioactivity of flavonoids is significantly influenced by their conversion by gut microbes.

Purpose of the Study:

  • To explore the role of flavonoid metabolism in the gut microbiome.
  • To investigate the connection between flavonoid-derived compounds and the gut microbiome-brain axis.
  • To understand how microbial flavonoid conversion impacts metabolic and cognitive health.

Main Methods:

  • Literature review on flavonoid metabolism and gut microbiome.
  • Analysis of existing studies on diet, obesity, and cognitive function.
  • Exploration of the biochemical pathways of flavonoid conversion by gut bacteria.

Main Results:

  • Gut microbial conversion is essential for the bioactivity of many flavonoids.
  • Flavonoid-derived metabolites can influence host physiology, including metabolic parameters and neurological function.
  • Evidence suggests a functional link between gut microbial activity, flavonoid metabolism, and the gut microbiome-brain axis.

Conclusions:

  • Flavonoid metabolism by gut microbes is critical for their health benefits.
  • Flavonoid-derived neuroactive compounds are key players in the gut microbiome-brain axis.
  • Targeting microbial flavonoid conversion may offer novel strategies for managing obesity and cognitive decline.