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Clinical and Haematological Manifestations of Typhoid Fever in Children in Eastern Turkey

S Akbayram1, M Parlak2, M Dogan3

  • 1Department of Pediatric Hematology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.

The West Indian Medical Journal
|March 21, 2017
PubMed

Insights

Typhoid fever in children often presents with abdominal pain and fever. Key hematological findings include decreased mean platelet volume and anemia, which may aid early diagnosis.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hematology

Background:

  • Typhoid fever presents with diverse clinical manifestations, ranging from uncomplicated to severe organ involvement.
  • Hematological alterations such as anemia, leukopenia, and thrombocytopenia are frequently observed in typhoid fever patients.
  • Understanding the clinical and hematological profile of typhoid fever in children is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the clinical and hematological characteristics of typhoid fever in pediatric patients.
  • To identify common symptoms and hematological findings associated with typhoid fever in children.
  • To explore potential early diagnostic clues for typhoid fever in the pediatric population.

Main Methods:

  • Retrospective analysis of medical records of children and adolescents (≤16 years) diagnosed with typhoid fever.
  • Data collection from patients admitted to Yuzuncu Yil University Hospital between 2010 and 2014.
  • Evaluation of clinical symptoms and hematological parameters, including platelet count, mean platelet volume, and white blood cell counts.

Main Results:

  • The majority of cases (56%) were admitted during July and October.
  • Common clinical symptoms included abdominal pain (24%), arthralgia (21%), and fever (11%).
  • Frequent hematological findings were decreased mean platelet volume (31%), eosinopenia (20%), abnormal platelet count (19%), anemia (16%), leucocytosis (16%), and eosinophilia (12%).

Conclusions:

  • Typhoid fever predominantly affects school-aged children, with a slight male predominance.
  • Decreased mean platelet volume and the presence of abdominal pain may serve as valuable early indicators for diagnosing typhoid fever in children.
Abstract

Keywords:
Childmean platelet volumetyphoid fever

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