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Published on: June 21, 2017
General Methodology for the Preparation of Unsymmetrical α-Linked Bisenones via Ligandless Cross-Coupling Reactions
David R Williams1, Seth A Bawel1
1Department of Chemistry, Indiana University , 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, United States.
Abstract:
A stereocontrolled Stille cross-coupling reaction, involving the use of Pd2dba3, provides a general procedure for the synthesis of unsymmetrical α-linked bisenone systems. The transformation is achieved in the absence of phosphine ligands under conditions that promote the stabilization of "ligandless" palladium catalysis. The extension of these studies illustrates Suzuki-Miyaura reactions of 2-boryl-2-cyclohexen-1-one with iodide and triflate partners for the synthesis of novel electron-deficient 1,3-dienes.
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