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Related Experiment Video

Updated: Mar 6, 2026

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
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Acquired pendular nystagmus.

Sarah Kang1, Aasef G Shaikh1

  • 1Department of Neurology, Case Western Reserve University, Cleveland, OH, USA; Daroff-DelOsso Ocular Motility Laboratory, Neurology Service, Louis Stoke VA Medical Center, Cleveland, OH, USA.

Journal of the Neurological Sciences
|March 22, 2017
PubMed
Summary
This summary is machine-generated.

Acquired pendular nystagmus involves eye oscillations affecting vision. This review covers its causes, like multiple sclerosis, and mimics, offering insights into pathophysiology and potential treatments.

Keywords:
Degenerative disorderDemyelination disorderMultiple sclerosisStrokeToxin exposure

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Area of Science:

  • Ophthalmology
  • Neurology
  • Neuroscience

Background:

  • Acquired pendular nystagmus (APN) presents as quasi-sinusoidal eye oscillations.
  • APN significantly impairs gaze holding and visual acuity.
  • Common causes include demyelinating diseases (e.g., multiple sclerosis) and ocular palatal tremor syndrome.

Purpose of the Study:

  • To review the clinical features of neurological deficits associated with APN.
  • To discuss the pathophysiology of various forms of APN.
  • To explore potential pharmacotherapy for APN.

Main Methods:

  • Review of clinical features of neurological deficits.
  • Analysis of kinematic features of APN.
  • Discussion of underlying disease mechanisms and pharmacotherapy.

Main Results:

  • Identified common and mimicking causes of APN.
  • Linked kinematic features to putative pathophysiology.
  • Provided insights into potential therapeutic strategies.

Conclusions:

  • APN is associated with diverse neurological deficits.
  • Understanding APN pathophysiology aids in identifying underlying conditions.
  • Pharmacological interventions may help manage APN symptoms.