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Related Experiment Video

Updated: Mar 6, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
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Bioactive Molecule Delivery Systems for Dentin-pulp Tissue Engineering.

Suja Shrestha1, Anil Kishen1

  • 1Discipline of Endodontics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Journal of Endodontics
|March 22, 2017
PubMed
Summary

Controlled release of bioactive molecules (BMs) from biomaterial carriers enhances regenerative endodontics. Spatial- and temporal-controlled delivery systems show promise for dentin-pulp tissue engineering and clinical translation.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Endodontics

Background:

  • Regenerative endodontics utilizes bioactive molecules (BMs) for cell signaling.
  • Bolus delivery of BMs can lead to rapid diffusion and denaturation, hindering therapeutic effects.

Purpose of the Study:

  • To review polymeric strategies for controlled release of BMs in dentin-pulp tissue engineering.
  • To explore advancements in regenerative endodontic procedures.

Main Methods:

  • Narrative review of polymeric bioactive molecule release strategies.
  • Focus on controlled release systems for dentin-pulp engineering.

Main Results:

  • Controlled release from biomaterial carriers can enhance tissue engineering in regenerative endodontics.
Keywords:
Bioactive molecule carriersbioactive moleculesdentin-pulp engineeringodontogenic differentiationstem cellstemporal-controlled release

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  • Spatial- and temporal-controlled release systems mimic natural healing processes.

    • Conclusions:

    • Controlled bioactive molecule release systems offer a promising approach for dentin-pulp tissue engineering.
    • Further validation is needed for clinical translation of these regenerative endodontic strategies.