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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

1.9K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

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Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
75
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

65
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
65
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

75
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

568
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Updated: Mar 6, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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ISMP Adverse Drug Reactions.

Michael A Mancano

    Hospital Pharmacy
    |March 22, 2017
    PubMed
    Summary

    This feature aims to increase awareness of adverse drug reactions (ADRs) and promote their reporting to the US Food and Drug Administration's (FDA) MedWatch program for improved patient safety.

    Area of Science:

    • Pharmacovigilance
    • Medication Safety

    Background:

    • Adverse drug reactions (ADRs) pose a significant risk to patient safety.
    • Effective reporting systems are crucial for monitoring and mitigating drug-related harm.

    Purpose of the Study:

    • To enhance awareness of specific ADRs.
    • To discuss strategies for preventing ADRs.
    • To encourage reporting of ADRs to the FDA's MedWatch program.

    Main Methods:

    • This initiative disseminates information on ADRs.
    • It provides guidance on ADR prevention.
    • It serves as a platform for sharing preventable ADR case reports.

    Main Results:

    • Increased reporting of ADRs to MedWatch is anticipated.

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    Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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  • Heightened awareness of ADRs among healthcare professionals and patients is a key outcome.
  • Sharing of practical prevention strategies will be facilitated.

    • Conclusions:

    • Promoting ADR awareness and reporting is vital for medication safety.
    • Collaboration between healthcare institutions and regulatory bodies enhances pharmacovigilance.
    • Sharing real-world ADR experiences contributes to safer medication use.