Related Experiment Video
Updated: Mar 6, 2026

10:36
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
21.0K
First Foods and Gut Microbes
Martin F Laursen1, Martin I Bahl1, Kim F Michaelsen2
1National Food Institute, Technical University of Denmark Søborg, Denmark.
Frontiers in Microbiology
|March 22, 2017
Summary
The introduction of solid foods during infancy significantly shapes the gut microbiota, impacting a child's long-term health. This crucial developmental window offers opportunities for microbial interventions.
Area of Science:
- Microbiology
- Pediatrics
- Nutrition Science
Background:
- Early-life gut microbiota establishment influences later health and disease.
- Gut microbial composition is affected by delivery mode, antibiotics, location, and feeding type in the first months.
- Microbial development continues until age 3, representing a critical window for modulation.
Purpose of the Study:
- To summarize existing research on complementary diet effects on infant gut microbiota.
- To highlight the impact of transitioning to family foods on gut microbial diversity.
- To discuss potential implications for child health and identify research gaps.
Main Methods:
- This perspective paper synthesizes findings from limited studies on complementary feeding and gut microbiota.
- It reviews current literature on the impact of dietary transitions in early childhood.
- Focuses on the period between 6 and 24 months, coinciding with complementary feeding.
Main Results:
- The transition to family foods significantly impacts the development of gut microbial diversity in infants.
- Early dietary interventions can influence the gut microbiome during a critical developmental window.
- Limited studies currently exist, indicating a need for more research.
Conclusions:
- The complementary feeding period is a key "window of opportunity" for modulating the gut microbiota.
- Understanding these dietary impacts is crucial for promoting healthy child development.
- Further research is essential to elucidate the long-term health consequences of early gut microbial development.
Related Concept Videos
Anatomy of the Intestines
88.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
88.8K
Bacterial Flora of the Large Intestine
1.8K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K
What is Monogastric Digestion?
76.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
76.5K
Development of Immunocompetence
1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Neural Regulation
43.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.8K
Physiology of Enteric Nervous System and Gut Health
1.1K
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
1.1K

