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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

468
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

419
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Risk-adapted HLA delisting and imlifidase-enabled deceased-donor kidney transplantation in highly sensitized kidney transplant candidates: a German expert consensus report.

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Related Experiment Video

Updated: Mar 6, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
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Published on: October 11, 2014

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ABO-Incompatible Kidney Transplantation.

Christian Morath1, Martin Zeier1, Bernd Döhler2

  • 1Department of Nephrology, University of Heidelberg , Heidelberg , Germany.

Frontiers in Immunology
|March 22, 2017
PubMed
Summary
This summary is machine-generated.

Abo-incompatible kidney transplants are now routine, achieving survival rates similar to compatible transplants. While desensitization strategies are effective, increased infectious complications require careful monitoring in patients undergoing ABO-incompatible kidney transplantation.

Keywords:
ABO incompatibleantibodiesdesensitizationkidney transplantationsurvival

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Last Updated: Mar 6, 2026

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Area of Science:

  • Nephrology
  • Transplantation Immunology

Background:

  • ABO-incompatible (ABOi) kidney transplantation was historically contraindicated.
  • Organ shortages have driven the development of strategies to overcome ABO antibody barriers.

Purpose of the Study:

  • To review recent evidence on ABO-incompatible kidney transplantation.
  • To focus on desensitization strategies and their outcomes.

Main Methods:

  • Review of recent evidence and Collaborative Transplant Study data.
  • Focus on desensitization protocols involving apheresis and B cell-depleting therapies.
  • Analysis of outcomes including graft survival and infectious complications.

Main Results:

  • ABOi kidney transplantation is now a routine procedure with outcomes comparable to compatible transplantations.
  • Desensitization protocols achieve acceptable anti-A/B antibody levels.
  • Increased infectious complications, including viral disease and severe UTIs, are noted, with one additional death per 100 ABOi recipients in the first year.

Conclusions:

  • ABOi kidney transplantation is a viable option due to advancements in desensitization.
  • While graft survival is comparable, heightened vigilance for infectious complications is crucial.
  • Further understanding of accommodation phenomena is needed.