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Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Neeta K Venepalli1, Mary V Modayil1, Stephanie A Berg1

  • 1Neeta K Venepalli, Tad D Nair, Mayur Parepally, Priyanka Rajaram, Yue Huang, Department of Medicine, Section of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL 60612, United States.

World Journal of Hepatology
|March 22, 2017
PubMed

Insights

Hispanic patients with hepatocellular carcinoma (HCC) face higher risks of metabolic conditions like nonalcoholic steatohepatitis (NASH) and experience shorter overall survival (OS). This highlights disparities in HCC outcomes among racial groups.

Area of Science:

  • Hepatology
  • Oncology
  • Epidemiology

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • Understanding racial and ethnic disparities in HCC is crucial for targeted interventions.
  • Previous research indicates variations in HCC characteristics across different populations.

Purpose of the Study:

  • To compare the clinical and demographic features of hepatocellular carcinoma (HCC) in Hispanic patients against those in African American and White patients.
  • To identify specific risk factors and comorbidities associated with HCC in the Hispanic population.

Main Methods:

  • Retrospective analysis of 195 patients diagnosed with HCC between 2005 and 2011 at an urban tertiary medical center.
  • Data collection included demographics, comorbidities, liver disease characteristics, tumor parameters, treatment, and overall survival (OS).
  • Kaplan-Meier method was used for overall survival analyses.

Main Results:

  • Hispanic patients (22.6%) were more likely to have diabetes, hyperlipidemia, nonalcoholic steatohepatitis (NASH), and end-stage renal disease compared to African American (31.2%) and White (46.2%) patients.
  • Hispanic patients had a lower incidence of hepatitis C virus (HCV) and smoking history.
  • Hispanic patients exhibited higher MELD scores, ascites, and encephalopathy, and experienced shorter overall survival (OS) than other racial groups.

Conclusions:

  • Hispanic patients with HCC demonstrate a higher prevalence of modifiable metabolic risk factors, including NASH.
  • These patients experience significantly shorter overall survival (OS) compared to African American and White patients.
  • Findings underscore the need for focused strategies to address metabolic health and improve HCC outcomes in Hispanic populations.
Abstract

Keywords:
EpidemiologyHepatocellular carcinomaHispanicsSurvivalTreatment pattern

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