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An update on migraine: current understanding and future directions.
Francesca Puledda1,2, Roberta Messina1,2, Peter J Goadsby3,4
1Headache Group, Department of Basic and Clinical Neuroscience, King's College London, London, UK.
Journal of Neurology
|March 22, 2017
Summary
Migraine involves complex brain network dysfunction. Recent research advances have led to novel therapies like CGRP antagonists and neuromodulation, improving patient care.
Area of Science:
- Neuroscience
- Neurology
- Pharmacology
Background:
- Migraine is a prevalent neurological disorder characterized by significant disability.
- It involves complex interactions within central and peripheral nervous system networks.
- Recent interest has elucidated neurophysiological mechanisms and neurotransmitter roles.
Purpose of the Study:
- To review current understanding of migraine pathophysiology.
- To discuss novel therapeutic agents for migraine management.
- To cover both pharmacological and neuromodulation approaches.
Main Methods:
- Literature review of recent advancements in migraine research.
- Analysis of neurophysiological mechanisms and neurotransmitter involvement.
- Overview of emerging therapeutic strategies.
Main Results:
- Identification of abnormal neuronal networks in migraine.
- Elucidation of key neurotransmitters in migraine pathophysiology.
- Emergence of targeted therapies including CGRP antagonists and ditans.
- Advancement in neuromodulation techniques for migraine treatment.
Conclusions:
- Understanding migraine pathophysiology has accelerated therapeutic innovation.
- Novel treatments offer improved clinical management options for migraine patients.
- A combination of pharmacological and neuromodulation approaches may optimize care.
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