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Metastatic melanoma moves on: translational science in the era of personalized medicine

Mitchell P Levesque1, Phil F Cheng2, Marieke I G Raaijmakers2

  • 1Department of Dermatology, University of Zurich, University of Zurich Hospital, Gloriastrasse 31, CH-8091, Zurich, Switzerland. Mitchell.Levesque@usz.ch.

Cancer Metastasis Reviews
|March 22, 2017
PubMed

Insights

Advances in metastatic melanoma treatment stem from research and improved in vitro models. Understanding resistance mechanisms and utilizing next-generation sequencing and advanced cell cultures will drive future therapies.

Area of Science:

  • Oncology
  • Cancer Research
  • Melanoma Research

Background:

  • Metastatic melanoma treatment has advanced due to decades of research.
  • Improved in vitro models are crucial for understanding disease progression.

Purpose of the Study:

  • To review current therapeutic options for metastatic melanoma.
  • To discuss genetic and non-genetic resistance mechanisms.
  • To highlight in vitro tools aiding melanoma research.

Main Methods:

  • Review of latest therapeutic strategies.
  • Analysis of genetic and non-genetic resistance mechanisms.
  • Evaluation of in vitro tools like next-generation sequencing and advanced cell cultures (2D and 3D).

Main Results:

  • Next-generation sequencing and complex cell models offer significant insights.
  • These tools facilitate functional testing of genomic data.
  • Understanding resistance is key to developing effective treatments.

Conclusions:

  • The integration of hypothesis-generating and testing approaches is vital.
  • Advanced in vitro models and genomic technologies will shape future melanoma therapies.
  • Continued research is essential for overcoming treatment resistance.
Keywords:
3D cultureBioengineered skinMelanomaMelanoma treatmentSkin reconstructsTranslational research

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