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Updated: Oct 9, 2026

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model
Published on: October 16, 2017
Neoplastic transformation of the rat visceral yolk sac by polyoma virus
Y L Lu1, H Sobis, M Vandeputte
1University of Leuven, Rega Institute, Belgium.
Abstract:
The transforming activity of polyoma virus was verified in vitro in organ cultures of 12-day old rat visceral yolk sacs and embryos. Organ cultures of 18-day old fetal organs were also included. The transforming capacity of the virus was found to be restricted to the endothelial cells of the rat visceral yolk sac. The neoplastic endothelial cells are readily transplantable and possess the polyoma tumor-specific transplantation antigens (TSTA).
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