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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Cancer Imaging in Immunotherapy.

Yousra Eleneen¹, Rivka R Colen²

¹Department of Cancer Systems Imaging and Diagnostic Radiology-Neuro Imaging, The University of Texas MD Anderson Cancer Center, T. Boone Pickens Academic Towe (FCT16.5037), 1515 Holcombe Blvd., Unit 1482, Houston, TX, 77030, USA.

Advances in Experimental Medicine and Biology

|March 22, 2017

Summary

This summary is machine-generated.

Immune therapies offer new cancer treatments but present unique imaging responses. This review covers traditional and novel imaging criteria for evaluating these responses and associated adverse events.

Keywords:

Cancer imaging Immune imaging criteria Immunotherapy irRC irRECIST

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Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

Area of Science:

Oncology
Immunology
Radiology

Background:

Cancer immunotherapy is a rapidly advancing field.
Immunotherapy elicits distinct imaging patterns compared to conventional chemotherapy.
Traditional RECIST criteria may not accurately reflect treatment response in immunotherapy.

Purpose of the Study:

To review traditional and novel imaging response criteria for solid tumors treated with immunotherapy.
To discuss the challenges in interpreting imaging findings during immunotherapy.
To highlight common immunotherapy-induced adverse events.

Main Methods:

Review of existing literature on imaging response criteria.
Comparison of RECIST, immune-related Response Evaluation Criteria in Solid Tumors (irRECIST), and immune-related Response Criteria (irRC).
Discussion of characteristic imaging findings in immunotherapy.

Main Results:

Immunotherapy responses can include delayed tumor shrinkage, transient enlargement, stable disease, or new lesions.
Novel criteria like irRECIST and irRC are being developed to better assess immunotherapy efficacy.
FDA approval still largely relies on traditional RECIST criteria.

Conclusions:

Accurate assessment of immunotherapy requires understanding unique imaging patterns.
Development and implementation of immune-related criteria are crucial for clinical trials.
Radiologists and oncologists must be aware of these evolving criteria and potential adverse events.