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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Mar 6, 2026

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

Published on: August 18, 2018

Therapeutic Hypothesis Testing With Rodent Brain Tumor Models.

Derek A Wainwright^1,2,3, Craig M Horbinski^1,4, Rintaro Hashizume^1,5

¹Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics

|March 22, 2017

Summary

Rodent models are crucial for preclinical testing of brain tumor therapeutics. This review emphasizes patient-derived xenografts for evaluating experimental therapies before clinical trials.

Keywords:

Immunocompetent vs. immunocompromised Spontaneous vs. engraftment Syngeneic Xenograft

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Published on: June 23, 2023

Area of Science:

Neuro-oncology
Preclinical Research
Translational Medicine

Background:

Rodent models have been foundational in neuro-oncology for decades.
These models are essential for assessing experimental therapies prior to human trials.
Advancements include genetically engineered mouse models, but core principles remain.

Purpose of the Study:

To review common rodent brain tumor models.
To evaluate their utility in preclinical therapeutic testing.
To focus specifically on patient-derived xenograft models.

Main Methods:

Discussion of genetically engineered mouse models.
Overview of syngeneic rodent models.
Detailed examination of patient-derived xenograft models.

Main Results:

Genetically engineered models spontaneously or inducibly develop tumors.
Syngeneic models involve engrafting tumor cells into syngeneic rodents.
Patient-derived xenografts utilize human tumor cells in immunocompromised rodents.

Conclusions:

Patient-derived xenografts are highlighted for their preclinical therapeutic evaluation potential.
Rodent models continue to be vital for advancing brain tumor treatments.
The review provides insights into selecting appropriate models for drug development.