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Related Concept Videos

Polymers02:34

Polymers

42.1K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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Proteoglycans01:05

Proteoglycans

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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

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Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
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Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

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Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
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Self-Assembling Brush Polymers Bearing Multisaccharides.

Jongchan Lee1, Jin Chul Kim1,2, Hoyeol Lee1

  • 1Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, and Polymer Research Institute, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.

Macromolecular Rapid Communications
|March 22, 2017
PubMed
Summary
This summary is machine-generated.

Brush polymers with various saccharide moieties were synthesized. These materials form self-assembling films with saccharide-rich surfaces, showing high affinity for concanavalin A and low protein binding, suitable for biosensors.

Keywords:
multibilayer structuremultisaccharidesproteinssaccharide-containing brush polymerssaccharide-enriched polymer film surfaceself-assemblyspecific binding

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Surface Chemistry

Background:

  • Brush polymers offer unique properties for surface modification.
  • Saccharide moieties can impart specific biological recognition capabilities.
  • Controlling surface composition is crucial for biomedical applications.

Purpose of the Study:

  • To synthesize novel brush polymers with defined saccharide end-groups (glucosyl, maltosyl, maltotriosyl).
  • To investigate the self-assembly behavior and film-forming properties of these polymers.
  • To evaluate the surface characteristics and protein-binding properties for potential biomedical uses.

Main Methods:

  • Cationic ring-opening polymerization for polymer backbone synthesis.
  • Postmodification reactions to attach specific saccharide moieties.
  • Film formation and surface analysis techniques (e.g., ellipsometry, XPS).
  • Binding studies with concanavalin A and plasma proteins.

Main Results:

  • Successful synthesis of brush polymers with glucosyl, maltosyl, and maltotriosyl end-groups.
  • Formation of multibilayer structures in films, leading to saccharide-enriched surfaces.
  • Demonstrated high specific binding affinity to concanavalin A.
  • Significant suppression of nonspecific plasma protein binding.

Conclusions:

  • Brush polymers with saccharide moieties exhibit remarkable self-assembly properties.
  • Saccharide-enriched surfaces show excellent specific recognition and reduced nonspecific interactions.
  • These polymers are highly promising for advanced biomedical applications, particularly in biosensor development.