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Elevated High Sensitivity C-Reactive Protein Increases the Risk of Microalbuminuria in Subjects With Cardiovascular

Shi-Kun Yang1, Jun Liu1, Bin Yi1

  • 1Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|March 22, 2017
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) is linked to microalbuminuria, an early sign of kidney damage, in adults with cardiovascular disease risk factors. Elevated hs-CRP amplifies kidney deterioration, highlighting chronic inflammation's role.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Chemistry

Background:

  • Microalbuminuria is a crucial early indicator of kidney injury.
  • Cardiovascular disease (CVD) risk factors are prevalent and associated with kidney damage.
  • The role of chronic inflammation, as indicated by high-sensitivity C-reactive protein (hs-CRP), in microalbuminuria among individuals with CVD risk factors requires further investigation.

Purpose of the Study:

  • To investigate the association between hs-CRP levels and the presence of microalbuminuria in adults with CVD risk factors.
  • To determine if hs-CRP can independently predict microalbuminuria.
  • To assess the impact of elevated hs-CRP on microalbuminuria risk in the context of established CVD risk factors.

Main Methods:

  • A cross-sectional study involving 5667 adult subjects attending annual health screenings.
  • Logistic regression analysis was employed to assess the association between hs-CRP, CVD risk factors, and microalbuminuria.
  • Receiver Operating Characteristic (ROC) curve analysis was used to identify an optimal hs-CRP cut-off value for screening microalbuminuria.

Main Results:

  • Elevated hs-CRP was significantly associated with microalbuminuria, independent of traditional CVD risk factors.
  • Multivariate analysis confirmed that high hs-CRP (≥0.85 mg/L) independently predicted microalbuminuria (OR 1.41).
  • In subjects with CVD risk factors, elevated hs-CRP further increased the risk of microalbuminuria (e.g., OR 1.71 in hypertension).

Conclusions:

  • Elevated hs-CRP is an independent predictor of microalbuminuria in adults with CVD risk factors.
  • Chronic inflammation, indicated by hs-CRP, may exacerbate kidney damage in individuals with existing CVD risk factors.
  • hs-CRP holds potential as a screening biomarker for early kidney injury in at-risk populations.

Keywords:
Cardiovascular risk factorsCross-sectional studyMicroalbuminuriahigh sensitivity C-reactive protein

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