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Muscarinic receptor-mediated intracellular Ca2+ mobilization in embryonic chick heart cells
H Schmidt1, G Oettling, U Drews
1Anatomisches Institut der Universität Tübingen, FRG.
FEBS Letters
|March 28, 1988
Abstract:
Activation of muscarinic receptors of heart cells elevates the intracellular Ca2+ concentration. The increase is considered to be due to influx of extracellular Ca2+. We show that intracellular Ca2+ mobilization is involved. Cell suspensions prepared from hearts of 6-day-old chick embryos were loaded with the fluorescent Ca2+ chelator chlortetracycline. Muscarinic stimulation induces a dose-dependent fluorescence decrease (ED50 = 2.6 x 10(-6) M) indicating intracellular Ca2+ mobilization.