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Updated: Mar 6, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Thyroid Hormones, Metabolic Syndrome and Its Components.
Alessandro P Delitala1, Giuseppe Fanciulli2, Giovanni M Pes2
1Clinica Medica, Azienda Ospedaliero Universitaria di Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Metabolic syndrome, a cluster of conditions including diabetes and obesity, is a growing global health issue. This review explores how thyroid hormones influence metabolic syndrome components like lipid and glucose metabolism.
Area of Science:
- Endocrinology and Metabolism
- Public Health
Background:
- Metabolic syndrome is a widespread health concern characterized by diabetes, obesity, hypertension, and abnormal lipid levels.
- Its prevalence varies but is higher in older populations, significantly increasing cardiovascular risk and mortality.
- Emerging evidence suggests a connection between thyroid function and metabolic syndrome components.
Purpose of the Study:
- To review the current understanding of thyroid hormone actions on metabolic syndrome.
- To elucidate the role of thyroid hormones in energy homeostasis, lipid and glucose metabolism, and blood pressure regulation within the context of metabolic syndrome.
Main Methods:
- Literature review of existing studies on thyroid function and metabolic syndrome.
- Synthesis of data on the physiological effects of thyroid hormones on key metabolic parameters.
Main Results:
- Thyroid hormones play a crucial role in regulating energy balance, lipid profiles, and glucose metabolism.
- Alterations in thyroid function are associated with various components of the metabolic syndrome.
Conclusions:
- Thyroid hormones significantly impact the development and progression of metabolic syndrome.
- Understanding this relationship is vital for managing metabolic syndrome and its associated cardiovascular risks.
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