Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning-based design and experimental validation of a medicine-like human antibody library.

Briefings in bioinformatics·2025
Same author

Superoxide dismutase SOD-3 regulates redox homeostasis in the intestine.

microPublication biology·2024
Same author

Matrixed CDR grafting: A neoclassical framework for antibody humanization and developability.

The Journal of biological chemistry·2023
Same author

Fused in sarcoma regulates glutamate signaling and oxidative stress response.

Free radical biology & medicine·2023
Same author

Development of an anti-<i>Pseudomonas aeruginosa</i> therapeutic monoclonal antibody WVDC-5244.

Frontiers in cellular and infection microbiology·2023
Same author

First Tarsometatarsal Joint Fusion for Hallux Valgus Deformity: A Retrospective Comparison of Two Fixation Constructs Regarding Initial Maintenance of Correction and Complications: Traditional Crossing Screw Fixation Versus Dorsomedial Locking Plate and Intercuneiform Compression Screw.

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons·2022

Related Experiment Video

Updated: Mar 6, 2026

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

10.0K

Superoxide dismutase SOD-1 modulates C. elegans pathogen avoidance behavior.

Alexander M Horspool1, Howard C Chang1

  • 1Department of Biological Sciences, Binghamton University, SUNY, Binghamton, NY 13902, USA.

Scientific Reports
|March 22, 2017
PubMed
Summary
This summary is machine-generated.

The C. elegans nervous system uses superoxide dismutase-1 (SOD-1) in gustatory neurons to initially tolerate, then avoid, pathogenic bacteria. This delayed avoidance may enhance survival by allowing temporary nutrient use from contaminated food sources.

More Related Videos

A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins
08:37

A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins

Published on: April 30, 2018

8.2K
Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans
09:36

Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans

Published on: March 23, 2019

7.7K

Related Experiment Videos

Last Updated: Mar 6, 2026

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

10.0K
A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins
08:37

A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins

Published on: April 30, 2018

8.2K
Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans
09:36

Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans

Published on: March 23, 2019

7.7K

Area of Science:

  • Neuroscience
  • Microbiology
  • Genetics

Background:

  • The nervous system's response to infection-induced reactive oxygen species (ROS) is poorly understood.
  • Pathogenic microbes trigger physiological and behavioral defenses in C. elegans.

Purpose of the Study:

  • To investigate how the C. elegans nervous system responds to pathogen-associated oxidative stress.
  • To elucidate the role of superoxide dismutase-1 (SOD-1) in mediating pathogen avoidance behavior.

Main Methods:

  • Studied gene expression of SOD-1 in C. elegans gustatory neurons upon exposure to Pseudomonas aeruginosa.
  • Utilized genetic knockdown experiments to assess the function of SOD-1 in pathogen avoidance.
  • Analyzed the role of reactive oxygen species (ROS) in activating SOD-1 dependent behaviors.

Main Results:

  • SOD-1 expression in the ASER neuron is induced upon initial P. aeruginosa encounter and diminishes with prolonged exposure.
  • Reduced SOD-1 expression correlates with the initiation of pathogen avoidance behavior.
  • Pathogen-induced ROS non-cell-autonomously activate sod-1 dependent behavioral responses.

Conclusions:

  • SOD-1 in the ASER neuron plays a critical role in C. elegans' adaptive response to pathogenic bacteria.
  • Delayed pathogen avoidance, mediated by SOD-1 and ROS, may offer a survival advantage.
  • Redox homeostasis influences the behavioral response to harmful microbes, impacting food-seeking behavior.