Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity
Binh T D Trinh1, Tam T T Quach2, Dung N Bui2
1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark; Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Abstract:
Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7±0.5 and 14.1±3.5μM, respectively.
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