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Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite,
A Brennan1, D R Katz, J D Nunn
1Bland-Sutton Institute of Pathology, University College and Middlesex School of Medicine, London, U.K.
Immunology
|August 1, 1987
Abstract:
Dendritic cells have been isolated from human tonsillar tissue and shown to act as accessory cells in a mitogenic response. The dendritic cells will induced receptors for the active metabolite of vitamin D3, 1,25(OH)2D3, in the responder E+ T cells. The dendritic cells themselves constitutively express receptors for the metabolite, and this distinguishes them from other non-T cells in lymphomedullary tissue. Expression of the 1,25(OH)2D3 receptor may be a dendritic cell property that facilitates their accessory cell role within the tissue microenvironment.