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Autism Spectrum Disorder01:19

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Related Experiment Video

Updated: Mar 6, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

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An autism-associated serotonin transporter variant disrupts multisensory processing.

J K Siemann1, C L Muller1, C G Forsberg2

  • 1Neuroscience Program, Vanderbilt University, Nashville, TN, USA.

Translational Psychiatry
|March 22, 2017
PubMed
Summary

Children with autism spectrum disorder (ASD) show altered multisensory processing. A genetic mouse model of autism demonstrated deficits in integrating sensory information, implicating the serotonin system in these changes.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Autism Spectrum Disorder Research

Background:

  • Altered sensory processing and integration are common in autism spectrum disorder (ASD).
  • The serotonin system plays a crucial role in sensory development and function, with alterations implicated in ASD.
  • A specific serotonin transporter (SERT) variant linked to sensory aversion in humans and ASD-like traits in mice was previously identified.

Purpose of the Study:

  • To investigate multisensory function in a genetic mouse model with a gain-of-function SERT variant associated with ASD traits.
  • To determine if disruptions in multisensory integration are present in this mouse model compared to wild-type (WT) littermates.

Main Methods:

  • Mice were trained on independent auditory and visual tasks.
  • Behavioral responses were assessed under unimodal (visual, auditory) and multimodal (audiovisual) conditions.
  • Performance of SERT mutant mice was compared to WT mice.

Main Results:

  • Wild-type mice showed enhanced response accuracy when integrating auditory and visual stimuli (multisensory gain).
  • SERT mutant mice learned unimodal tasks similarly to WT mice.
  • However, SERT mutant mice failed to exhibit behavioral gains under multisensory audiovisual conditions.

Conclusions:

  • This study provides the first behavioral evidence of multisensory processing deficits in a genetic mouse model relevant to ASD.
  • Results suggest the serotonin system is involved in multisensory integration.
  • The findings implicate the serotonin system in the multisensory alterations observed in autism spectrum disorder.