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Related Experiment Video

Updated: Mar 6, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

An autism-associated serotonin transporter variant disrupts multisensory processing.

J K Siemann¹, C L Muller¹, C G Forsberg²

¹Neuroscience Program, Vanderbilt University, Nashville, TN, USA.

Translational Psychiatry

|March 22, 2017

Summary

Children with autism spectrum disorder (ASD) show altered multisensory processing. A genetic mouse model of autism demonstrated deficits in integrating sensory information, implicating the serotonin system in these changes.

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Published on: December 7, 2018

Area of Science:

Neuroscience
Developmental Neuroscience
Autism Spectrum Disorder Research

Background:

Altered sensory processing and integration are common in autism spectrum disorder (ASD).
The serotonin system plays a crucial role in sensory development and function, with alterations implicated in ASD.
A specific serotonin transporter (SERT) variant linked to sensory aversion in humans and ASD-like traits in mice was previously identified.

Purpose of the Study:

To investigate multisensory function in a genetic mouse model with a gain-of-function SERT variant associated with ASD traits.
To determine if disruptions in multisensory integration are present in this mouse model compared to wild-type (WT) littermates.

Main Methods:

Mice were trained on independent auditory and visual tasks.
Behavioral responses were assessed under unimodal (visual, auditory) and multimodal (audiovisual) conditions.
Performance of SERT mutant mice was compared to WT mice.

Main Results:

Wild-type mice showed enhanced response accuracy when integrating auditory and visual stimuli (multisensory gain).
SERT mutant mice learned unimodal tasks similarly to WT mice.
However, SERT mutant mice failed to exhibit behavioral gains under multisensory audiovisual conditions.

Conclusions:

This study provides the first behavioral evidence of multisensory processing deficits in a genetic mouse model relevant to ASD.
Results suggest the serotonin system is involved in multisensory integration.
The findings implicate the serotonin system in the multisensory alterations observed in autism spectrum disorder.