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Strategies to Target Glucose Metabolism in Tumor Microenvironment on Cancer by Flavonoids
Gang Wang1,2, Jun-Jie Wang1,2, Rui Guan2
1a Department of Pharmaceutics , Jiangsu University , Shanghai , China.
Abstract:
The imbalance between glucose metabolism and cancer cell growth in tumor microenvironment (TME), which are closely related with the occurrence and progression of cancer. Accumulating evidence has demonstrated that flavonoids exert many biological properties, including antioxidant and anticarcinogenic activities. Recently, the roles and applications of flavonoids, particularly in relation to glucose metabolism in cancers, have been highlighted. Thus, the identification of flavonoids targeting alternative glucose metabolism pathways in TME may represent an attractive approach to the more effective therapeutic strategies for cancer. In this review, we will focus on the roles of flavonoids in regulating glucose metabolism and cancer cell growth in TME, such as proliferation advantage, cell mobility, and chemoresistance to cancer, as well as modifiers of thermal sensitivity. Not only have such large-scale endeavors been useful in providing fundamental insights into natural and synthesized flavonoids that can prevent and treat cancer, but also have led to the discovery of potential targets for cancer therapy.
Insights
Flavonoids regulate cancer cell growth and glucose metabolism within the tumor microenvironment (TME). Identifying flavonoids targeting cancer
Area of Science:
- Oncology
- Biochemistry
- Metabolomics
Background:
- Cancer progression is linked to imbalances in glucose metabolism within the tumor microenvironment (TME).
- Flavonoids possess antioxidant and anticarcinogenic properties, with emerging roles in cancer glucose metabolism.
- Understanding flavonoid interactions with cancer cell metabolism is crucial for developing novel therapeutic strategies.
Purpose of the Study:
- To review the role of flavonoids in modulating glucose metabolism and cancer cell growth in the TME.
- To explore how flavonoids impact cancer hallmarks like proliferation, mobility, chemoresistance, and thermal sensitivity.
- To identify potential therapeutic targets for cancer treatment based on flavonoid activity.
Main Methods:
- Literature review focusing on studies investigating flavonoids, glucose metabolism, and cancer.
- Analysis of research on flavonoid mechanisms in regulating cancer cell proliferation, migration, and drug resistance.
- Examination of flavonoids' influence on thermal sensitivity in cancer cells within the TME.
Main Results:
- Flavonoids can modulate key aspects of cancer cell metabolism and growth in the TME.
- Specific flavonoids demonstrate potential in targeting alternative glucose metabolism pathways.
- Flavonoids influence cancer cell proliferation, mobility, chemoresistance, and thermal sensitivity.
Conclusions:
- Flavonoids represent promising agents for targeting cancer's metabolic vulnerabilities.
- Targeting glucose metabolism pathways with flavonoids offers a potential avenue for effective cancer therapy.
- Further research into natural and synthesized flavonoids can uncover new therapeutic strategies and targets for cancer treatment.
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