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Thymic Carcinoma With Endobronchial Metastasis: A Case Report
Makoto Nagamata1, Yusuke Okuma, Yukio Hosomi
1Departments of *Thoracic Oncology and Respiratory Medicine †Pathology, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Honkomagome, Bunkyo, Tokyo, Japan.
Thymic carcinoma, a rare cancer, can present as rare endobronchial metastases. This case highlights a patient with thymic squamous cell carcinoma and bilateral lung tumors, treated successfully with chemotherapy.
Area of Science:
- Oncology
- Thoracic Surgery
- Pulmonology
Background:
- Thymic carcinoma is a rare malignancy comprising 1-4% of thymic epithelial tumors.
- Endobronchial metastasis is an uncommon presentation for thymic malignancies.
Observation:
- A 64-year-old male presented with a cough and a left pulmonary hilum mass.
- Imaging revealed an anterior mediastinal mass and left upper lobe infiltrate.
- Bronchoscopy identified bilateral polypoid tumors in the bronchi.
Findings:
- Biopsies confirmed squamous cell carcinoma positive for c-KIT.
- Video-assisted thoracoscopic surgery diagnosed thymic squamous cell carcinoma with bilateral endobronchial metastases (Masaoka-Koga stage IVb).
Implications:
- This case underscores the importance of considering thymic carcinoma in the differential diagnosis of endobronchial tumors.
- The patient achieved a partial response to platinum-doublet chemotherapy, suggesting its efficacy in advanced thymic carcinoma with metastasis.
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