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Cutaneous pathology following etoposide therapy
B K Yokel1, K J Friedman, E R Farmer
1Department of Dermatology, Johns Hopkins University, Baltimore, MD 21205.
Journal of Cutaneous Pathology
|December 1, 1987
Summary
Etoposide (VP-16) therapy can cause unique skin rashes with characteristic "starburst cells" in keratinocytes. These findings may indicate abnormal cell division due to this chemotherapy agent.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Etoposide (VP-16), a podophyllotoxin derivative, treats various cancers.
- Known side effects include Stevens-Johnson syndrome and radiation recall.
- Cutaneous eruptions are an underreported complication of etoposide treatment.