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Chocolate consumption and risk of stroke among men and women: A large population-based, prospective cohort study

Jia-Yi Dong1, Hiroyasu Iso1, Kazumasa Yamagishi2

  • 1Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Atherosclerosis
|March 22, 2017
PubMed

Insights

This study found that regular chocolate consumption was linked to a lower risk of stroke in women, but not in men. Further research is needed to confirm these findings on chocolate and stroke risk.

Area of Science:

  • Nutritional Epidemiology
  • Cardiovascular Disease Research
  • Public Health Nutrition

Background:

  • Limited prospective cohort data exists on chocolate consumption and cardiovascular health.
  • Investigating the association between chocolate intake and stroke risk is crucial for public health recommendations.

Purpose of the Study:

  • To examine the prospective association between chocolate consumption and the risk of stroke in a large Japanese population cohort.
  • To differentiate potential effects by sex and stroke subtypes.

Main Methods:

  • A large cohort of 38,182 men and 46,415 women (aged 44-76) were followed for incident stroke.
  • Chocolate consumption data was collected using a food frequency questionnaire.
  • Cox proportional hazards regression models were employed to analyze stroke risk.

Main Results:

  • A total of 3,558 incident strokes were recorded during a median follow-up of 12.9 years.
  • Chocolate consumption was associated with a significantly lower risk of stroke in women (HR=0.84; 95% CI, 0.71-0.99).
  • No significant association was observed between chocolate consumption and stroke risk in men (HR=0.94; 95% CI, 0.80-1.10).

Conclusions:

  • Findings suggest a significant inverse association between chocolate consumption and stroke risk in women within this Japanese cohort.
  • The observed association in women warrants further investigation, acknowledging potential residual confounding.
Abstract

Keywords:
ChocolateProspective cohort studyStroke

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