A clinic compatible, open source electrophysiology system.

Area of Science:

• Neuroscience
• Biomedical Engineering
• Medical Devices

Background:

• Open-source electrophysiology (ephys) systems offer customization and affordability.
• Existing systems like Open-Ephys and NeuroRighter excel in research but lack clinical compatibility.
• There is a need for open-source, clinic-compatible ephys systems for acute human studies, especially in operating rooms.

Purpose of the Study:

• To develop an affordable, open-source electrophysiology recording system suitable for clinical environments.
• To create a system that meets the safety and technical requirements for acute human electrocorticography (ECoG) research in the operating room.
• To validate the system's performance in a real-world clinical setting.

Main Methods:

• Designed and built an open-source ephys system with features including power isolation, water-resistant enclosures, and 256 recording channels.
• Sampled neural data at up to 20 kS/sec with 16-bit resolution.
• Validated the system by performing high-density ECoG recordings during an acute, awake craniotomy study.

Main Results:

• The developed system is affordable (<$10,000) and open-source.
• The system successfully recorded high-density ECoG data in an operating room environment.
• Key features include patient safety through power isolation and robust, compact hardware.

Conclusions:

• An affordable, open-source electrophysiology system has been successfully developed and validated for clinical use.
• This system facilitates acute human ECoG research in operating rooms, overcoming previous limitations.
• The technology enhances accessibility and customization for critical neuroscientific investigations.