Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-linear relationship between triglyceride glucose-body mass index and risk of diabetes in adults: a general population-based cohort study of Chinese adults using a publicly available DRYAD dataset.

Frontiers in endocrinology·2026
Same author

Biomechanical consequences of minor medial joint line elevation after medial unicompartmental knee arthroplasty.

Journal of orthopaedic surgery and research·2026
Same author

Development and validation of a clinical nomogram for predicting suboptimal concentration of valproate in pediatric with epilepsy: a retrospective study.

Frontiers in pharmacology·2026
Same author

Early-life high-fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations.

FEBS open bio·2026
Same author

Arsenic Inhibits the PA28α/β-PSMB5 Pathway Blocking Phosphorylated TFEB Degradation and Causing Lysosomal Dysfunction that Damages the Liver.

Biological trace element research·2026
Same author

An Antipolarity Luminescence Enhancement in Dy/Eu@Gd-MOFs Induced by Isomeric Solvents.

The journal of physical chemistry. B·2026

Related Experiment Video

Updated: Mar 5, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

7.9K

Adipose Tissue-Derived Pericytes for Cartilage Tissue Engineering.

Jinxin Zhang1, Chunyan Du2, Weimin Guo1

  • 1Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics; Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA; 28 Fuxing Road, Haidian District, Beijing 100853, China.

Current Stem Cell Research & Therapy
|March 23, 2017
PubMed
Summary

Adipose tissue-derived pericytes offer a promising, readily available cell source for cartilage regeneration, bypassing the need for extensive culture of mesenchymal stem cells (MSCs). Further preclinical research is essential to optimize their clinical application in tissue engineering.

Keywords:
CD146Pericytesadipose tissue-derived stromal vascular fraction (AT-SVF)adipose-derived stem cells (ADSCs)cartilage tissue engineeringchondrogenic progenitor cells (CPCs)magnetic- activated cell sorting (MACS)

More Related Videos

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.9K
Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint
12:06

Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint

Published on: August 2, 2022

2.4K

Related Experiment Videos

Last Updated: Mar 5, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

7.9K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.9K
Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint
12:06

Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint

Published on: August 2, 2022

2.4K

Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Cell Biology

Background:

  • Mesenchymal stem cells (MSCs) are a potential source for cartilage tissue engineering but require labor-intensive ex vivo expansion, posing clinical risks.
  • Pericytes, often considered the origin of MSCs, are found in adipose tissue and can be used without extensive culture.
  • Adipose tissue provides an accessible reservoir of pericytes, suitable for immediate autologous use in cartilage regeneration.

Purpose of the Study:

  • To highlight adipose tissue-derived pericytes as a promising cell source for cartilage regeneration.
  • To address the limitations of current MSC-based approaches for cartilage repair.

Main Methods:

  • Isolation of adipose tissue-derived stromal vascular fraction (AT-SVF) via lipoaspiration.
  • Sorting of pericytes from AT-SVF.
  • Development of automated isolation and cell sorting techniques (SVF device, magnetic-activated cell sorting).

Main Results:

  • Automated methods enable efficient sorting of large numbers of viable pericytes for clinical use.
  • These advancements facilitate the development of one-step surgical procedures for cartilage repair.

Conclusions:

  • Adipose tissue-derived pericytes show significant potential for cartilage tissue engineering.
  • Further preclinical studies are required to enhance cell purity, improve sorting efficiency, and evaluate safety for clinical applications.