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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Citric acid crosslinked β-cyclodextrin/carboxymethylcellulose hydrogel films for controlled delivery of poorly
Vishwajeet Sampatrao Ghorpade1, Adhikrao Vyankatrao Yadav2, Remeth Jacky Dias1
1Department of Pharmaceutics, YSPM's Yashoda Technical Campus, Wadhephata, Satara, 415011, Maharashtra, India.
Abstract:
Citric acid crosslinked β-cyclodextrin-carboxymethylcellulose (βCD-CMC) hydrogel films were prepared by esterification-crosslinking method for the controlled release of ketoconazole (model drug). The hydrogel films were evaluated for active βCD content, carboxyl content, swelling ratio, drug loading and release, and hemolytic activity. The structural characterization was carried out using solid state 13C NMR, ATR-FTIR, TGA and DSC analysis. The βCD-CMC hydrogel films showed increase in active βCD content swelling ratio and drug loading with increase in the concentration of βCD in the feed. The βCD helped to minimize the burst effect and retarded the release of ketoconazole. The hydrogel films were found to be biocompatible and capable of controlling the release of ketoconazole for long duration.
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