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A novel framework for understanding reduced awareness of dyskinesias in Parkinson's Disease

Sara Palermo1, Leonardo Lopiano2, Maurizio Zibetti1

  • 1Department of Neuroscience, Via Cherasco 15, 10126 Turin, Italy.

Parkinsonism & Related Disorders
|March 23, 2017
PubMed
Abstract

Insights

Parkinson's disease patients with dyskinesias-reduced-self-awareness (DRSA) show deficits linked to "Theory of Mind" (ToM) and executive functions, not just metacognition.

Area of Science:

  • Neuroscience
  • Neurology
  • Psychology

Background:

  • Dyskinesias-reduced-self-awareness (DRSA) in Parkinson's disease (PD) is associated with metacognitive deficits.
  • The role of "Theory of Mind" (ToM) in DRSA in PD requires further investigation.

Purpose of the Study:

  • To investigate the influence of ToM, specifically Reading the Mind in the Eyes (RME) task, on DRSA in Parkinson's disease patients.
  • To explore the relationship between motor and executive function assessments and DRSA in PD.

Main Methods:

  • Forty-one PD patients were evaluated using the Global Awareness of Movement Disorders (GAM) and Dyskinesias Subtracted-Index (DS-I).
  • Multiple logistic regression analyses were performed to assess the impact of RME task performance and executive function tests (Trail Making Test B-A) on GAM and DS-I scores.

Main Results:

  • A significant association was found between GAM and DS-I scores and the RME task.
  • The DS-I scores also showed a significant association with the Trail Making Test B-A version, indicating a link with executive functions.

Conclusions:

  • DRSA in Parkinson's disease is influenced by the affective component of ToM and executive functions.
  • These findings suggest DRSA results from a complex interaction between specific neuropsychological factors and motor symptoms in PD.
Keywords:
DyskinesiasParkinson's diseaseReading the Mind in the EyesSelf-awarenessTheory of Mind

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