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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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New concepts of personalized therapy in salivary gland carcinomas

Gunter Keller1, Diana Steinmann2, Alexander Quaas3

  • 1Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany; Department of Cranio-Maxillo-Facial Surgery, Henriettenstift, Hannover, Germany.

Oral Oncology
|March 23, 2017
PubMed

Insights

Personalized therapy for salivary gland carcinomas is emerging, focusing on targeted treatments and novel approaches like immunomodulation and nanoparticles. These strategies aim to overcome resistance to traditional therapies and improve patient outcomes for these rare tumors.

Area of Science:

  • Oncology
  • Translational Medicine

Background:

  • Salivary gland carcinomas are rare with non-standardized therapy strategies.
  • Surgical resection is primary, but incomplete removal due to nerve infiltration is common.
  • Radio- and/or chemotherapy resistance limits treatment options.

Purpose of the Study:

  • To review novel concepts for personalized therapy in salivary gland carcinoma.
  • To highlight potential molecular targets and emerging treatment modalities.

Main Methods:

  • Literature review of current and emerging therapeutic strategies.
  • Analysis of molecular targets and resistance mechanisms in salivary gland carcinomas.

Main Results:

  • Targeting growth receptors (HER2, EGFR, AR, ER) shows promise but requires adequate pre-therapy testing.
  • RAS mutations (H-RAS) are present in 20-25% of carcinomas, potentially causing therapy resistance.
  • Emerging options include immunomodulation (PDL1/PD1 inhibition), nanoparticles, and drug delivery systems (T-DM1).

Conclusions:

  • Personalized therapy offers new hope for salivary gland carcinoma patients.
  • Future treatments may involve targeted therapies, immunomodulation, and advanced drug delivery systems.
  • Further research is needed to optimize the application of these novel strategies.
Keywords:
Personalized therapySalivary gland carcinoma

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